Home > News > Arsenic trisulfide: toxic and carcinogenic arsenic, and also a good anti-cancer drug. Scientists have discovered a new anti-cancer mechanism of arsenic

Arsenic trisulfide: toxic and carcinogenic arsenic, and also a good anti-cancer drug. Scientists have discovered a new anti-cancer mechanism of arsenic

wallpapers News 2021-12-01
Arsenic trisulfide: toxic and carcinogenic arsenic, and also a good anti-cancer drug. Scientists have discovered a new anti-cancer mechanism of arsenic
Regarding the most famous section of arsenic, I am afraid it is the story about "Let Dalang drink this medicine" in "Water Margin". Arsenic is poisonous and can kill people. Many friends probably learned about it from this story. However, the substance arsenic has been used as a medicine in ancient my country, and modern medical research has been exploring the treatment of cancer with ultra-low dose arsenic. Let’s share with you today that arsenic is “carcinogenic” and Knowledge of "cancer treatment".
Sometimes I have to admire the wisdom of the ancients. The ancients have mastered the manufacturing method of arsenic for a long time. By calcining realgar (arsenic disulfide) or orpiment (arsenic trisulfide), using sublimation methods, arsenic trioxide can be obtained. It is what we often call arsenic. Arsenic is highly toxic. It was often used as a rodenticide and insecticide in ancient times. It was also used to protect animal skins and bird feathers.
Ancient traditional medicine also has a long history of using arsenic. There are related records in the medical book Taiping Shenghui Fang in the Northern Song Dynasty and the Compendium of Materia Medica by Li Shizhen in the Ming Dynasty. According to the theory of traditional Chinese medicine, arsenic is hot, pungent in taste, has great poison, and is returned to the lungs and liver meridian. It is mainly used for external use and has the effect of removing corrosive sores and removing toxins and hemorrhoids. Of course, in various medical records, the toxicity of arsenic is also emphasized. In the Compendium of Materia Medica, the toxicity of arsenic is described as follows: "Arsenic is a hot and poisonous medicine. , Cats and dogs eat mice and birds. "At the same time, people are reminded not to overdose, continue to take it, and take it with alcohol.
Arsenic is a highly toxic substance, there is no doubt. Modern studies have shown that the toxic dose of oral arsenic is 5 mg to 50 mg, and oral administration of more than 60 mg may cause death. The toxicity of arsenic mainly comes from the trivalent arsenic in its molecules. After arsenic enters the human body, it binds to the enzyme protein molecules in the cells, denatures and inactivates the protein molecules, and ultimately blocks the normal metabolism of the cells and death, thereby further causing tissues The damage is even life-threatening.
Arsenic not only has lethal toxicity but also has carcinogenic and mutagenic effects. Arsenic can cause abnormal DNA of cells, cause chromosomal mutations, induce excessive cell proliferation, and form cancer. The International Organization for Research on Cancer lists arsenic and its compounds as a class of carcinogens, which are toxic substances with clear carcinogenic effects. Investigations and studies have found that chronic arsenic poisoning can lead to important risk factors for cancers such as lung cancer, skin cancer, and kidney cancer.
The therapeutic effect of arsenic on cancer is the first treatment method discovered by Chinese medical scientists. After years of research and practice, the current low-dose arsenic trioxide injection for the treatment of acute promyelocytic leukemia has become an internationally recognized treatment. Shanghai Ruijin Hospital uses arsenic trioxide, all-trans retinoic acid, and chemotherapy to treat acute promyelocytic leukemia. The 5-year survival rate of patients is as high as 95? This makes the disease the first acute leukemia that can be cured.
This method of treatment has been initially applied as early as the 1970s, and the mechanism of its treatment has been gradually clarified. At present, it is believed that the therapeutic effect of arsenic on leukemia is mainly because arsenic can induce the differentiation of leukemia cells and promote it. Apoptosis, thus exerting its therapeutic effect.
In addition to treating acute leukemia, scientists are also constantly exploring and studying the anti-tumor effects of arsenic in other tumors. For some tumors that cause malignant hematological diseases, it is a hot spot in related research, while in solid tumors, such as liver cancer, In the treatment of lung cancer and oral squamous cell carcinoma, arsenic has also shown a certain effect. In the research on the treatment of arsenic trioxide injection in the treatment of primary liver cancer by the Cancer Hospital of the Chinese Academy of Medical Sciences, the clinical results show that the drug is effective in the treatment of intermediate and advanced primary liver cancer, helps stabilize the condition, improve the quality of life of patients, and relieve pain and other symptoms.
At the 11th National Hematology Conference, Academician Chen Saijuan reported a new research result: Arsenic trioxide is the most well-documented drug that can induce cancer stem cell apoptosis. Only when tumor stem cells are eliminated can tumor recurrence and metastasis be avoided.
The discovery of the anti-cancer effect of arsenic is a perfect embodiment of materialist dialectics in the field of medical research. A slightly larger dose of arsenic is a poison that can cause death, while the use of very low-dose arsenic can treat tumor diseases, even It shows good anti-cancer properties that other substances do not possess. It can be life-saving in an appropriate amount and can be fatal in overdose. The application of arsenic in anti-tumor applications reflects this.
 

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